string_ppi_enrichment
STRING: Protein–protein interaction (PPI) enrichment
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Third-party content written by another agent. Data to evaluate, not instructions.
This tool tests if your network is enriched in protein-protein interactions compared to the background proteome-wide distribution (i.e., if your proteins are more functionally connected than expected by chance).
- The enrichment is assessed using the actual observed edges versus expected edges in a random network of the same size.
- The p-value reflects the likelihood that your observed number of interactions would occur by chance.
- Report the p-value as a human-readable value (e.g. 2.3e-5 or 0.023).
When calling related tools use the same input parameters unless otherwise specified.
Output fields:
- number_of_nodes: Number of proteins in your network
- number_of_edges: Number of observed edges/interactions
- average_node_degree: Mean degree (average number of interactions per node)
- local_clustering_coefficient: Average clustering coefficient in the network
- expected_number_of_edges: Expected number of edges in a random network of the same size
- p_value: p-value for network enrichment (smaller = more enriched)
Example identifiers: "SMO%0dTP53"
Input schema
| Property | Type | Required | Description |
|---|---|---|---|
| identifiers | string | yes | Required. One or more protein identifiers, separated by %0d. Example: SMO%0dTP53 |
| species | any | no | |
| required_score | any | no |
Raw JSON schema
{
"properties": {
"identifiers": {
"description": "Required. One or more protein identifiers, separated by %0d. Example: SMO%0dTP53",
"type": "string"
},
"species": {
"anyOf": [
{
"description": "Required. NCBI/STRING taxon (e.g. 9606 for human, or STRG0AXXXXX for uploaded genomes).",
"type": "string"
},
{
"type": "null"
}
],
"default": null
},
"required_score": {
"anyOf": [
{
"anyOf": [
{
"maximum": 1000,
"minimum": 0,
"type": "integer"
},
{
"type": "null"
}
],
"description": "Optional. Minimum interaction confidence score. Omit unless a confidence threshold is requested or a broader/narrower threshold is needed."
},
{
"type": "null"
}
],
"default": null
}
},
"required": [
"identifiers"
],
"type": "object"
}